Mechanisms of synaptic plasticity during cortex-dependent learning
Project B09 deals mainly with cortex-dependent auditory discrimination learning in rodents that is also part of the integrative paradigm. Based on our previous findings we will address the following questions: (i) What is the role of phospholipase Cβ signalling in the formation/consolidation of late memories? (ii) What is the role of bassoon-mediated presynaptic plasticity in learning and memory? (iii) What brain region- and cell type-specific changes in synaptic proteomes occur during memory formation? In particular, what are the molecular mechanistic differences between aversively and appetitively reinforced learning and memory processes?