CRC 779

Neurobiology of Motivated Behavior

Project A06

Modulation of excitation/inhibition balance by NMDAR antagonism in depression

Dr. Martin Walter

Prof. Dr. Martin Walter

Dr. sc. nat. Anna Fejtová

Prof. Dr. Anna Fejtová

We will investigate the cellular mechanisms by which the NMDAR antagonist Ketamine changes the brains functional network. These therapeutically desired neuronal changes will then be investigated for their influence on negative attentional bias in depression prone individuals. This translation is reached by combined investigation of molecular and systems levels in analogous experiments in humans and mouse models.